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1 tablet once daily or as directed by physician.
Dosage must be individualized on the basis of both effectiveness and tolerance, while not exceeding the maximum recommended daily dose.
The maximum recommended daily dose of metformin in adults is 2000 mg and glimepiride is 8 mg once daily.
Do not crush or chew the tablet; the whole tablet to be taken with water. Start with one tablet per day. The aim should be to decrease both fasting plasma glucose and glycosylated hemoglobin levels to normal by using the lowest effective dose of the drug.
